Nitric oxide release by N-(2-chloroethyl)-N-nitrosoureas: a rarely discussed mechanistic path towards their anticancer activity
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چکیده
منابع مشابه
Release of 7-alkylguanines from N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea-modified DNA by 3-methyladenine DNA glycosylase II.
Purified bacterial 3-methyladenine DNA glycosylase II releases four 7-alkylguanines from [3H]N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea-modified DNA: 7-(2-hydroxyethyl)guanine,1,2-bis(7-guanyl)ethane, 7-(2-chloroethyl)guanine, and 7-(2-ethoxyethyl)guanine. 7-(2-Ethoxyethyl)guanine, a new compound, is formed as a result of an interaction with ethanol, a common solvent for the 2-haloethylnitro...
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N-methyl-D-aspartate (NMDA) elicits pial arteriolar dilation that has been associated with neuronal nitric oxide (NO) production. However, endothelial factors or glial P-450 epoxygenase products may play a role. We tested whether NMDA-induced pial vasodilation 1) primarily involves NO diffusion from the parenchyma to the surface arterioles, 2) involves intact endothelial function, and 3) involv...
متن کامل(Z)-N-(2-Chlorobenzylidene)aniline N-oxide
In the title compound, C(13)H(10)ClNO, the central C-N bond has considerable double-bond character and the N-O bond indicates a formal negative charge on the O atom. The mol-ecule is stabilized by an intra-molecular C-H⋯O hydrogen bond. The geometry about the C=N bond is Z [C-C-N-O torsion angle = -4.2 (3)°] and the phenyl and benzene rings are trans-oriented around the C=N bond. The phenyl and...
متن کاملATTEMPTED PREPARATION OF N-SUBSTITUTED DIPHENYLCYCLOPROPENEIMINE N-OXIDE
The reaction of diphenylcyclopropenone with several N-substituted hydroxylamine and primary amines are investigated. Most of these reactions led to ring opened or ring enlarged products, instead of the desired N-Oxide or imine. The reaction of cyclopropeneimine with peracid-another possible route to N-substituted cyclopropeneimine N-Oxide is studied. Most of the unexpected products are ide...
متن کاملN-[2-(2-Methoxyphenyl)benzylidene]-tert-butylamine N-oxide
In the mol-ecule of the title compound, C(18)H(21)NO(2), the two benzene rings are oriented at a dihedral angle of 58.19 (3)°. Intra-molecular C-H⋯O hydrogen bonds result in the formation of one six- and one five-membered ring, which adopt twist and envelope conformations, respectively. In the crystal structure, C-H⋯O hydrogen bonds link the mol-ecules.
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2015
ISSN: 2046-2069
DOI: 10.1039/c4ra11137k